A cerebrospinal fluid blood–brain barrier dysfunction score is associated with progression from mild cognitive impairment to Alzheimer's disease

CSF neuroinflammatory biomarkers are associated with amyloid-β42/40, tau pathology, and cognitive impairment across the Alzheimer’s disease spectrum

Linking cognitive variability and Alzheimer's disease biomarkers by neurocognitive status

Abstract INTRODUCTION This study aimed to assess intra‐individual cognitive variability (IICV) in relation to Alzheimer's disease (AD) biomarkers. METHODS The National Alzheimer's Coordinating Center sample (n = 879), aged 50+ with a complete neuropsychological evaluation and AD biomarker data available (64% cognitivel...

Neutrophil-to-lymphocyte ratio predicts early cognitive decline associated with tau pathology in Alzheimer's disease: a longitudinal study of the ADNI cohort.

Background Neuroinflammation is a key driver of Alzheimer's disease (AD). Although the neutrophil-to-lymphocyte ratio (NLR) is an easily accessible peripheral inflammatory marker, yet its longitudinal association with domain-specific cognitive decline and the underlying neuropathological mechanisms during the preclinic...

Prognostic significance of cerebrospinal fluid tau biomarkers in amyloid-negative A−T + N + neurodegeneration: A retrospective cohort study

Background Amyloid-negative tau-related neurodegeneration represents a non-Alzheimer biomarker-defined profile; however, its clinical heterogeneity and prognostic relevance remain unclear within Alzheimer's disease-related frameworks. Objective To characterize the clinical spectrum and identify predictors of mortality...

Associations of peripheral inflammation with hippocampal atrophy in Alzheimer's disease.

Peripheral inflammation has been implicated in Alzheimer's disease (AD), yet its links to hippocampal neurodegeneration and clinical progression remain incompletely defined. This study investigated associations of peripheral inflammatory markers with hippocampal volume fraction (HVF) and cognitive outcomes, alongside p...

CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer’s disease

Findings identify complement dysregulation, especially involving C1q, as an early correlate of tau-linked synaptic pathology, and support a role for complement activation in the AD molecular cascade.