COP9 complex maintains neuroblast growth and proliferation by regulating Akt/mTor pathway

Faf2 is required for neural differentiation in embryonic neural progenitor cells

It is shown that knocking out Faf2 in neural progenitor cells results in increased ER stress signature at the protein and transcription level, indicating a conserved functional role in neural progenitor cells.

Fine-tuning neuron number: Lzts as a key regulator of neurogenesis and cell proliferation in Ciona

These findings establish Ciona Lzts as a regulator of mitotic tempo determining the BTN number and suggest that this cell-cycle regulatory axis links proliferation to neurogenesis across chordates in vivo.

BBX maintains mammalian brain development by repressing p53-mediated p21 expression.

It is indicated that bobby sox homolog (BBX) maintains normal cortical development by restraining the p53-p21-RB axis, thereby preventing premature cell-cycle exit and senescence in developing neural cells.

Post-transcriptional regulation maintains neurogenic potential of human neural progenitor cells.

It is shown that Fragile X autosomal homolog 1 (FXR1), a brain-enriched RNA-binding protein (RBP), is essential for human neurogenesis, and post-transcriptional regulation is established as a key mechanism that maintains neurogenic potency of human NPCs.

Serine/Threonine phosphatase PP1 is a regulator of Notch signalling

Cell diversity generation is cardinal to the development of the functional central nervous system. The Notch pathway plays an important role in neurogenesis, spanning cell fate determination, cell death, and neural stem cell (NSC) competence switching, and is therefore highly regulated within cells. While the phosphory...

Presenilin-dependent ErbB4 Nuclear Signaling Regulates Astrogenesis via PARP1