Aug 2026· Frontiers in Pharmacology· Vol 17· 0 citations· 41 references
Medicine
TL;DR
The results suggest a more metabolically balanced state in the mice, and support the adjunctive use of CBD, as no adverse metabolic effects were observed in the brain, liver, or kidneys.
Abstract
Background Cannabidiol (CBD) has attracted renewed scientific attention for its therapeutic potential in human metabolism. However, the metabolic effects of CBD treatment remain incompletely understood. Methods This study investigated tissue-specific metabolic alterations in the brain, liver, and kidneys of Kramnik mice after 2 weeks of daily CBD treatment using an untargeted proton magnetic resonance (1H-NMR) metabolomics approach. Results Unsupervised principal component analysis (PCA) revealed minimal biological variation between the CBD-treated and control groups. The most notable, albeit minor, changes were observed in the brain and were associated with decreased signaling and neuroenergetics. The liver showed changes in sugar metabolism, and the kidneys showed only minor changes in phenylalanine levels. Discussion Collectively, our results suggest a more metabolically balanced state in the mice. These data support the adjunctive use of CBD, as no adverse metabolic effects were observed in the brain, liver, or kidneys.
Human exposure to 4,4'-diaminodiphenylmethane (MDA) occurs predominantly through dermal contact, yet its extra-hepatic biotransformation pathways and the metabolomic disturbances it induces remain poorly characterized. In this study, human skin fibroblasts were incubated with MDA, and untargeted LC-HRMS metabolomics wa...
L-Se-methylselenocysteine (L-SeMC) is a natural organic selenium compound with potential nutritional applications, but its acute disposition and metabolic responses remain incompletely characterized. Here, UPLC-QqQ-MS/MS was used to characterize L-SeMC pharmacokinetics and tissue distribution in H22 tumor-bearing mic...
Hon-Gan Li, Xin-Ru Tang, Hui Liu et al.· Journal of Agricultural and...· 0 citations
PTZ-induced kindling was associated with marked plasma metabolic alterations involving amino acid-, tryptophan-, and lipid-related pathways, which supports the broader relevance of metabolic dysregulation to epilepsy, while the mechanistic roles and biomarker potential of individual metabolites require independent vali...
Juan Ren, Fu-Li Wang, Zi-Jian Li et al.· Frontiers in Neuroscience· 0 citations
Reliable endogenous biomarkers for assessing CYP3A activity and clinical drug-drug interaction (DDI) risk remain limited. We characterized global metabolomic changes following itraconazole treatment in a fixed-sequence DDI study (11 healthy volunteers) to identify novel CYP3A endogenous biomarkers. Untargeted metabolom...
S. Yee, Eugene P. Kadar, Matthew A. Cerny et al.· Clinical pharmacology and th...· 0 citations
Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by infection with Echinococcus granulosus sensu lato, with the liver being the primary affected organ. This study aimed to investigate the metabolic profile alterations and differential regulation of the PPARγ signaling axis in proximal and distal hepati...
BACKGROUND
Prothioconazole (PTC) is one of the most widely used triazole fungicides worldwide, while its major metabolite, prothioconazole-desthio (dPTC), exhibits enhanced toxicological potential. However, the metabolic perturbations induced by chronic PTC exposure and sensitive biomarkers for exposure monitoring rema...
Lin-Lin Shi, Wen-Hui Li, Xian-Dan Zhu et al.· Pest Management Science· 0 citations
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