Aug 2026· Archives of pharmacal research· Vol 49, pp. 1073 - 1102· 0 citations· 62 references
Medicine
TL;DR
Findings support a hepatocyte-centered immunometabolic model in which Dex treatment is associated with α2-AR-dependent HPD regulation, altered hepatic HIF-1α levels, reduced neutrophil oxidative burst and NET formation, and attenuation of Th17 polarization and organ injury in sepsis.
Background Sepsis triggers dysregulated systemic inflammation and multiple-organ dysfunction, with the lungs being particularly susceptible to injury. Sepsis-induced acute respiratory distress syndrome (ARDS) is mainly driven by TLR4/NF-κB-mediated hyperinflammation and alveolar macrophage activation. Matrine, a bioact...
Xue Chen, Min Yuan, Ting Huang et al.· Drug Design, Development and...· 0 citations
Sepsis-associated liver injury is characterized by excessive inflammation and macrophage activation. β-Hydroxybutyrate (β-OHB) has anti-inflammatory effects and induces lysine β-hydroxybutyrylation (Kbhb), but the role of site-specific Kbhb in septic liver injury remains unclear. This study examined the role of STAT1 K...
Ya-Ping Bai, Kai Li, Dan Zhu et al.· Immunobiology· 0 citations
Sepsis often leads to severe liver damage, and currently few effective therapies are available for it. Nicotinamide mononucleotide (NMN), a well-known anti-aging agent, exerts organ-protective effects, yet its detailed mechanisms against acute liver injury remain poorly understood. Here, we established LPS-induced live...
Yan Liao, Cheng-Long Zhu, Wangzheqi Zhang et al.· Pharmacological Research· 0 citations
BACKGROUND
To investigate the protective role of dexmedetomidine (DEX) in sepsis-associated acute lung injury through the regulation of macrophage ferroptosis.
METHODS
In silico screening of GeneCards and FerrDb Vv3 databases was performed to identify ferroptosis-related candidate genes modulated by dexmedetomidineDE...
Bei Ma, Ren-Jie Luo, Gang Kuang et al.· Frontiers in Bioscience· 0 citations
It is demonstrated for the first time that Farrerol alleviates HIRI by downregulating macrophage CD14 expression, thereby inhibiting the downstream MyD88/NF-κB pathway and its associated inflammatory cascade, positioning FA as a promising therapeutic candidate and highlighting CD14 as a viable target for HIRI intervent...
Hong-Liang Liang, Jian-Sen Lu, Hao Pan et al.· International Immunopharmaco...· 0 citations
Parenteral nutrition-associated cholestasis (PNAC) arises from suppressed FXR signaling and macrophage activation driven by intestinal LPS and PN-derived phytosterols. We investigated whether tissue hypoxia and HIF1α signaling play a role in FXR-mediated protection in PNAC. PNAC mouse intrahepatic mononuclear cells (IH...
Swati Ghosh, M. Devereaux, David J. Orlicky et al.· Biochimica et Biophysica Act...· 0 citations
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