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Antimicrobial cetylpyridinium chloride disrupts the mitochondrial electron transport chain as potently as cyanide, via cardiolipin interference at cytochrome C

Emily L. Ledue Noah E. Adelman Madeleine K. Lorenger Dylan J. Wagner Sophie K. Trafton Esther Biro Emma R. Morrison Quinn W. D’Alessio John E. Burnell J. Gosse

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

CPC exhibits mitotoxicity as potent as cyanide, and the precise biochemical mechanism of action of this ubiquitous compound is determined to aid epidemiology, risk analysis, and predictive toxicology.

DOI Semantic Scholar

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