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Open access Aug 2026

Serum neurofilament light chain as a biomarker of inflammatory activity in relapsing-remitting multiple sclerosis: a real-world longitudinal cohort study

Abstract Objectives Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudina...

S. de las Heras Flórez, Gema García de la Rosa, Vicente Martín García et al. · 0 citations
Review Open access Aug 2026

EP1029 - ECE_1026 - Serum neurofilament light chain: a candidate biomarker of neuroaxonal injury in patients with dysnatremia, associated with functional outcomes and mortality

Both hypo- and hypernatremia are associated with neurocognitive and neuromuscular dysfunction. However, specific biomarkers for these complications are lacking. In the present study, we aimed to explore the association between serum sodium levels and serum neurofilament light chain (sNfL), an emerging circulating...

F. Bioletto, D. Cuboni, E. Varaldo et al. · 0 citations
Open access Aug 2026

Cerebrospinal Fluid Biomarkers of Neuroinflammation and Neuroplasticity in Type 2 Diabetes Mellitus: Association with Cognitive Performance

Background: Type 2 Diabetes Mellitus (T2DM) is associated with cognitive decline, potentially mediated by neuroinflammatory processes and altered neuroplasticity. This study investigated cerebrospinal fluid (CSF) biomarkers of neuroinflammation and neuroplasticity in T2DM individuals versus controls, and their relation...

C. M. Baracaldo Barrera, M. C. Jiménez Martínez, Sandra Rojas Vega · 0 citations
Open access Sep 2026

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progr...

G. Joseph, Megan McCune, R. Bove et al. · 0 citations
Open access Aug 2026

Correlation between the reduction of IL-6 and TNF-α with muscle mass restoration in hyperthyroid patients post-radioactive iodine therapy

Objective To investigate whether dynamic resolution of IL-6 and TNF-α after radioactive iodine (RAI) therapy is a key determinant of muscle recovery in Graves’ disease and to evaluate their potential as longitudinal biomarkers. Methods A prospective cohort of 157 patients with Graves’ disease was enrolled. Skeletal mus...

Yuqian Ren, Cui-Juan Zheng, Meng Wang et al. · 0 citations
Open access Sep 2026

Plasma neurofilament light chain in type 2 diabetes: Associations with diabetic peripheral neuropathy, age, and renal function in a pilot cross-sectional study

Background Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM). Neurofilament light chain (NfL) is a circulating marker of neuroaxonal injury, but its interpretation may be influenced by age and renal function. Objective To evaluate the association between plasma NfL concent...

M. Škorvanová, A. I. Verešpejová, J. Hanes et al. · 0 citations

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