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The findings suggest that multidomain integration provides an interpretable proof-of-concept framework for characterizing heterogeneous atrial remodeling and identifying potentially vulnerable substrate phenotypes.
Fibrosis, DNA damage-associated reduction in myocardial nuclear density, and advanced atrial amyloidosis are key determinants of atrial dysfunction and impaired postablation functional recovery in patients with AF.
ABSTRACT Background Low hemoglobin (Hb) is associated with hemodynamic stress and adverse cardiac remodeling. However, its clinical significance for arrhythmia recurrence after atrial fibrillation (AF) ablation remains unclear. Methods We retrospectively studied 2202 patients undergoing AF ablation between 2014 and 202...
Impaired RA reservoir strain was independently associated with TR progression in AF patients with initially insignificant TR, suggesting that RA functional assessment may provide additional information complementary to RA structural remodeling and help identify patients at higher risk of TR progression.
Risk models for atrial fibrillation (AF) recurrence after catheter ablation apply the same predictor structure to every patient. This overlooks the biological differences between early and advanced disease. We examined whether the clinical predictors of 12-month recurrence differ across four disease-stage phenoty...
In this large cohort with AS, AF was independently associated with an increased risk of both all-cause and cardiovascular mortality, regardless of treatment strategy or AS flow-gradient pattern.
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