2026· Advances in Immunology· Vol 171, pp.
175-203
· 0 citations
Medicine
TL;DR
iPSC-derived neuron, microglia, and astrocyte are used as models to study the spreading of pathological proteins and their contribution in the disease progression, providing insights into disease progression and potential therapeutic targets for neurodegenerative disease.
A “cellular state–pathological network–therapeutic window” framework is proposed and the roles of microglia in amyloid-β plaque seeding and compaction, NLRP3 inflammasome activation, mitochondrial DNA–cGAS–STING signaling, complement-mediated synaptic engulfment, and bidirectional microglia–tau feedback are systematica...
Lian-Jing Xu, Ying Zhang, Li Jiang et al.· Frontiers in Cellular Neuros...· 0 citations
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...
Almas Meheboob Pathan· International Journal of The...· 0 citations
The development of scalable iPSC-neuron models enables tauopathy drug discovery and reconstructs progressive Tau seeding, fibrillization and synaptic dysfunction, and establishes a physiologically relevant, scalable platform for therapeutic screening that connects Tau seed uptake, site-specific phosphorylation, fibril...
J. Lipka, Xiwei Shan, Qiao Zhang et al.· bioRxiv· 0 citations
An overview of modern techniques for generating 2-dimensional monocultures and co-cultures, 3-dimensional organoids and assembloids, and chimeras containing hiPSC-derived microglia and astrocytes is provided.
Rose Summers, D. Quang, Noah R. Johnson· International Journal of Mol...· 0 citations
HAMSC-EVs exert robust anti-inflammatory and neuroprotective effects in both murine and human AD models, improving cognition, modulating glial activation, and restoring synaptic integrity, and highlight the translational potential of intranasal hAMSC-EVs as an adjuvant therapeutic strategy targeting neuro inflammation...
Andrea Papait, F. Natale, A. Silini et al.· Translational Neurodegenerat...· 0 citations
Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.
Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al.· Molecular and cellular neuro...· 0 citations
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