Jul 2026· Open Access Government· Vol 51, pp. 190-191· 0 citations
Abstract
Heat shock factor 1 (HSF1) plays a pivotal role in maintaining neuronal health, and its dysfunction contributes significantly to the progression of Huntington’s disease. Rocio Gomez-Pastor tells us more. Huntington’s disease (HD) is a devastating, inherited neurodegenerative disorder marked by progressive motor dysfunction, cognitive decline, and psychiatric symptoms. At its genetic core lies a mutation in the huntingtin (HTT) gene, specifically an expansion of CAG trinucleotide repeats that encode an abnormally long polyglutamine (polyQ) tract in the huntingtin protein. (1) This mutation transforms an otherwise essential cellular protein into a toxic species prone to misfolding and aggregation. Over time, these molecular disturbances selectively damage neurons, particularly in the striatum and cortex. (2,3)
Huntington's disease (HD) is a life-threatening neurodegenerative disease caused by a mutation in Huntingtin (HTT). Neuropathology in HD is marked by a progressive loss of neurons in the caudate putamen and the deposition of mutant HTT aggregates as cytoplasmic and nuclear inclusions. At present, no disease-modifying t...
An Wu, Xue-Yi Li· Journal of Huntington's Dise...· 0 citations
Klotho is a promising neurochemical modulator with disease-modifying properties in HD, and its multifunctional protective activities are consistent with important pathological markers of HD, necessitating more preclinical and clinical studies to confirm its translational value.
Shikha Singh, Avnesh Kumar, Falguni Goel et al.· Current molecular medicine· 0 citations
Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the expansion of cytosine-adenine-guanine (CAG) repeats within the huntingtin (HTT) gene. Given their therapeutic potential, small-molecule strategies have gained significant traction, leading to the design of numerous lead candidate...
Yi-Tian Jiang, Xin-Yi Chen, Zhao-Xin Xu et al.· European journal of medicina...· 0 citations
Physical sign, behavioral, as well as increasing cognition are hallmarks of Huntington Disease (HD), a monogenic neurodegenerative illness that causes early impairment and death. In 1993, the genetic effect was identified as an enlarged Cytosine, Adenine, Guanine repeat on chromosome 4's exon 1 of the Huntington gene....
High mobility group box 1 (HMGB1) is a crucial modulator of neuroinflammation in AD, according to new research, and a viable treatment approach for reducing neuroinflammation and associated pathologies with AD is to target HMGB1-mediated signalling networks.
Prashant Tyagi, Sneha Kumari, Prajjwal Sharma et al.· International Immunopharmaco...· 1 citation
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