Jul 2026· The journals of gerontology. Series A, Biological sciences and medical sciences· Vol 81· 0 citations
Medicine
TL;DR
Linoleic acid and PUFAs showed consistent inverse associations with ARC, and docking suggested potential interactions between linoleic acid and candidate proteins.
Stroke is a leading cause of global mortality and morbidity, yet its underlying metabolic mechanisms remain largely undefined. Elucidating the causal role of blood metabolites in stroke pathogenesis is crucial for developing effective interventions. This study employed a two-sample Mendelian randomization (MR) framewor...
Luo Ding, Zhen-Yuan Li, Fu-Yuan Deng et al.· IUBMB Life - A Journal of th...· 0 citations
Using an MR-guided triangulation framework, eight systemic metabolomic signals associated with age-related cataract were prioritized, highlighting distinct systemic metabolic patterns that may inform future cataract biomarker and mechanistic studies.
Zhangluxi Liu, A. Lu, Siyuan He et al.· Translational Vision Science...· 0 citations
This large-scale proteome-wide Mendelian randomization study identified multiple plasma proteins with likely causal roles in EOS, implicating coagulation, platelet activation, extracellular matrix remodeling, and immune pathways in disease etiology.
A. Huynh, B. Gaynor, J. W. Cole et al.· medRxiv· 0 citations
Tobacco smoking increases the risk of multiple diseases, but the biological mechanisms involved remain incompletely understood. Here we characterize smoking-related protein profiles to identify potentially causal biomarkers mediating smoking’s effects. In European-ancestry populations, genetically predicted smoking exp...
A. Tinworth, P. Yao, A. Iona et al.· Nature Cardiovascular Resear...· 0 citations
This Mendelian randomization study revealed suggestive genetically predicted associations between 29 plasma proteins and bladder cancer risk, and implied that plasma lipidomic traits may partially mediate a subset of these relationships.
Qian Cao, Hong-Yan Liu, Yangyang Xu et al.· World journal of urology· 0 citations
Lower lymphocyte percentage and higher NMR-derived glucose had direct relationships with dementia in the joint constituent-biomarker network, supporting examination of composite exposures alongside their constituent biomarkers.
A. Baousi, K. Dobinda, J. Zhu et al.· medRxiv· 0 citations
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