2026· Advances in Protein Chemistry and Structural Biology· Vol 153, pp.
95-134
· 0 citations
Medicine
TL;DR
This chapter summarizes the recent progress that places kinases in a context-dependent state of molecular switches with disease-specific outcomes determined by structural conformation, spatiotemporal regulation, and network integration as opposed to kinase identity and describes the efficacy and drawbacks of first-generation ATP-competitive inhibitors.
The protein Mitogen-activated protein kinase 9 (MAPK9) (c-Jun N-terminal kinase 2 [JNK2]) is a critical signalling molecule involved in cellular survival, inflammation, oxidative stress, and the programming of cell death. This is because there has been emerging evidence of the effects of the abnormal activation of MAPK...
S. Otun, I. Achilonu· Exploration of Neuroscience· 0 citations
This review examines RCD as an integrated pathogenic network in major NDs as well as evaluating emerging therapeutic strategies that target cell death crosstalk, restore autophagy lysosomal competence, or improve delivery to the central nervous system.
Drug resistance remains a major barrier to durable targeted therapy, and cancer progression often reflects rewiring of signalling pathways that control protein stability. Dysregulation of the ubiquitin–proteasome system, including failure of degron-dependent substrate recognition, can stabilise oncogenic proteins, acce...
Jia-Xin Li, Shu-Han Liu, Lu Fu et al.· Frontiers in Cell and Develo...· 0 citations
A family of Oligopyridyl (OP) compounds are presented that are synthetically trivial, scalable, and potent antagonists of relevant aPPIs in the human brain.
Synaptic dysfunction and intracellular accumulation of pathological tau are convergent hallmarks of Alzheimer’s disease (AD) and related tauopathies, yet the molecular mechanisms coupling these events to widespread neurodegeneration remain incompletely understood. The Src family kinase Fyn has emerged as a critical sig...
Protein-protein interactions (PPIs) are critical for the physiological growth, development, and maintenance of all cells throughout the human body. However, genetic mutations, aging, and environmental exposures can lead to the induction of aberrant PPIs (aPPIs), which have been implicated in various ailments, including...
Tyler D. Ball· 0 citations
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