Differential methylation of immune-related genes and its clinical significance in systemic lupus erythematosus: insights from TET2, FOXP3, and IFI44L genes

IFI44L promoter hypomethylation as an epigenetic biomarker of systemic lupus erythematosus: A systematic review and meta-analysis.

IFI44L promoter hypomethylation represents a significant and reproducible epigenetic signature of SLE across populations and study designs and its diagnostic performance remains consistent, supporting IFI44L methylation as a promising biomarker for SLE.

MicroRNAs in systemic lupus erythematosus: Molecular networks, pathway dysregulation, and therapeutic targeting strategies

The role of miRNAs in SLE pathogenesis, their potential as biomarkers, and their emerging relevance as therapeutic targets are highlighted, while also addressing current limitations and challenges in clinical translation are addressed.

Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects

It is proposed that the precise modulation and enhancement of Treg function to restore stable immune tolerance in SLE patients constitutes a novel therapeutic paradigm, transitioning from broad immunosuppression toward targeted immune modulation.

Methylation of the MAPK1 Gene as a Potential Diagnostic and Prognostic Biomarker in Childhood B-Acute Lymphoblastic Leukemia

Background: Acute lymphoblastic leukemia is a type of heterogeneous leukemia that is associated with the abnormal proliferation of immature monoclonal B and T lymphoid precursors. Cancer is considered an epigenetic disease due to fundamental changes in the pattern of normal methylation in cancer cells. This study aimed...

MiR‑365b‑5p and MiR‑3614‑5p are elevated in PBMCs of systemic lupus erythematosus and exhibit potential as complementary diagnostic indicators

Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation that predominantly affects women of reproductive age. Genetic factors, particularly polymorphisms within the interleukin-10 (IL-10) promoter region, have been implicated in disease susceptibility through their i...