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The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

Ulrike Fuchs Sophie Schröder T. Pena D. Krüger Susanne Burkhardt Anna-Lena Schütz F. Sananbenesi A. Fischer

Jul 2026 · bioRxiv · 0 citations · 50 references

Medicine Biology

TL;DR

These findings identify Gm16685/MITA1 as a conserved lncRNA regulator of astrocyte reactivity and suggest that non-coding RNA dependent control of RNA binding proteins contributes to inflammatory signaling in neurodegenerative disease relevant contexts.

DOI PubMed Semantic Scholar

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