Design of Multi-Stimuli Responsive Nanocarriers for Co-delivery of Phytochemicals and Immune Modulators: A Synergistic Approach to Overcoming Tumor Resistance
This review examines the rationale for co-delivering phytochemicals and immune-modulating agents, two classes of therapeutics that act through complementary mechanism although not always synchronized.
The paper reviews current developments concerning stimulus-responsive nanoparticles; it also describes how these agents work as a means to treat cancers precisely.
C. J. Jiflin, Mohana Sundaram Somasundharam Pushpanathan, Jeevitha Dhayalan et al.· BOHR Journal of Pharmaceutic...· 0 citations
Abstract Tumor immunotherapy has substantially advanced cancer treatment by activating or enhancing the antitumor immune response. However, tumor heterogeneity, the immunosuppressive tumor microenvironment (TME), and therapeutic resistance limit the efficacy of single-agent immunotherapy, making mechanistically complem...
Tian-Ying Sun, Chuang Liu, Jiang Zhu et al.· International Journal of Nan...· 0 citations
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype lacking effective targeted therapies. Its tumor microenvironment (TME) exhibits distinct features, including acidity, redox imbalance, elevated reactive oxygen species (ROS), and hypoxia, which provide exploitable triggers for targeted drug...
Adnan Murad Bhayo, Ying Li, Alaa R. Aboushanab et al.· Pharmaceutics· 0 citations
Premature drug release in the systemic circulation or at off-target sites remains a major challenge in conventional drug delivery systems, often resulting in reduced therapeutic efficacy and increased systemic toxicity. Nanotechnology-based delivery platforms have emerged as promising strategies to address these limita...
U. Abbasi, Md. Saifuddin, Mahak Fatima et al.· Journal of drug targeting (P...· 0 citations
This review systematically summarizes targeted nanomedicines constructed from mainstream carriers, including polymeric, metallic, and biomimetic nanoparticles, and discusses the future prospects of artificial intelligence-assisted optimization strategies for nanomedicine development.
Rui-Chao Li, Ze-Yuan Sun, Si-Nian Li et al.· International Journal of Pha...· 0 citations
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