Aug 2026· Journal of Applied Clinical Medical Physics· Vol 27· 0 citations
Medicine
TL;DR
RatoGuide demonstrated favorable performance in typical cases, but accuracy declined in atypical cases with artifacts or altered anatomy, particularly for atypical cases and organs in high-dose gradient regions.
Abstract
Abstract Background Accurate contouring of target volumes and organs at risk is critical in radiotherapy. While deep learning (DL) models offer automated contouring, their clinical applicability to real‐world cases containing anatomical variations and artifacts requires rigorous validation. Purpose To evaluate the clinical accuracy and potential vulnerabilities of RatoGuide, novel DL‐based auto‐segmentation software, using a dataset including atypical cases derived from routine clinical practice. Methods This single‐center retrospective study included 69 thoracic and male pelvic cases. The cohort was intentionally selected to encompass diverse anatomies and artifacts (e.g., pacemakers, SpaceOAR implants, artificial femoral head replacements, and unilateral atelectasis). Auto‐contours generated by RatoGuide were compared with expert‐approved manual contours. Performance was evaluated quantitatively using the Dice Similarity Coefficient (DSC) and 95th percentile Hausdorff Distance (HD95), and qualitatively via a 5‐point visual assessment scale by four independent reviewers. Statistical comparisons between cohorts were performed using the Mann‐Whitney U test. Additionally, a dosimetric evaluation was conducted for male pelvic cases to assess clinical impact. Results In typical cases, the software maintained high segmentation accuracy (thorax: mean DSC 0.856, mean HD95 6.89 mm; male pelvis: mean DSC 0.874, mean HD95 4.11 mm). However, performance declined in atypical cohorts (thorax: mean DSC 0.808, p = 0.0457, mean HD95 12.22 mm, p = 0.0002; male pelvis: mean DSC 0.828, p = 0.1620, mean HD95 6.16 mm, p = 0.0075). Notable decreases in accuracy were observed in challenging scenarios, such as artificial femoral head replacements (DSC: 0.754) and unilateral atelectasis (DSC: 0.784). Qualitative assessment revealed that errors were primarily due to anatomical factors and artifacts. Furthermore, the dosimetric evaluation identified one critical false‐negative error where a dose constraint violation was overlooked when the DL contour was used. Conclusions RatoGuide demonstrated favorable performance in typical cases, but accuracy declined in atypical cases with artifacts or altered anatomy. For clinical implementation, rigorous visual verification and manual review by experts are essential, particularly for atypical cases and organs in high‐dose gradient regions.
MAGE explains how externalized knowledge, bounded action, independent evaluation, and retained human authority can compose into a governed engineering environment, and proposes tests of when that environment turns commodity intelligence into durable engineering progress.
James C. Davis, Kelechi G. Kalu, Huiyun Peng et al.· 1 citation
LLMs are increasingly used for code generation, yet they frequently hallucinate non-existent software packages, creating exploitable entry points into the software supply chain. We make four contributions to this problem. First, we show that prior evaluation methodologies systematically inflate hallucination rates by misclassifying standard-library modules as hallucinations in some languages. For Python, the overestimation reaches 9.4 percentage points. Second, we evaluate seven inference-time defenses for mitigating package hallucinations, including five guided decoding strategies (Greedy, Contrastive, DoLa, Nudging, and Active Layer-Contrastive Decoding), an iterative self-refinement approach (Self-Refine), and a Retrieval-Augmented Generation (RAG)-based defense.. Across eight models spanning five families and four programming languages (Python, JavaScript, Ruby, Rust), RAG reduces the package hallucination rate (PHR) in 18 of 32 model--language configurations. Third, we introduce Package Utility (PU) to assess whether defenses preserve valid and task-relevant recommendations. Among strategies evaluated, Greedy decoding provides the strongest average mitigation--utility trade-off. Fourth, we stress-test all strategies under adversarial prompts seeded with fabricated package names and find that PHR surges by up to 45 percentage points relative to standard prompts, with Ruby consistently the most vulnerable language (80.9--95.2\%). Under adversarial conditions, RAG and Self-Refine outperform all decoding-only strategies, indicating that robust defense requires either external grounding or iterative self-verification when prompts are actively hostile. Our results recast package hallucination as both a measurement problem and a decoding-time control problem, and they demonstrate that the choice of defense must be matched to the threat model and recommendation utility.
Albérick Euraste Djiré, Iyiola E. Olatunji, Melissa Tessa et al.· 1 citation
HawkEye is introduced, a modular, web-based vulnerability auditing platform designed to streamline security analysis by integrating multiple scanning tools within a unified dashboard and illustrates how consolidated reporting improves vulnerability prioritization for development teams.
D. R. Patil, Varad Salgare, Devaj Arya et al.· International Journal for Re...· 0 citations
By streamlining workflows and fostering collaboration, this platform offers a scalable, cost- effective solution for SMEs and contributes to software engineering by demonstrating how integrated technologies can modernize development processes in resource limited contexts, with potential for broader adoption in Albania and beyond.
OBJECTIVE
To prospectively evaluate whether modifying DSL version 5-based hearing aid (HA) fittings by adjusting gain on HA fitting software so that measured functional gain (FG) approached a one-third gain (1/3G) target could provide appropriate fitting outcomes in patients with sensorineural hearing loss.
METHODS
Twenty-four patients (48 ears) with bilateral sensorineural hearing loss underwent initial HA fitting using the DSL version 5 prescription formula. FG was measured at 250-4000 Hz, and HA gain was adjusted on HA fitting software so that FG approached the target 1/3 G. Speech discrimination scores at 65 and 80 dB SPL were evaluated after a two-week trial period using the 67-S Japanese monosyllable word list. Based on speech discrimination test results, ears were classified as well-fitting or non-well-fitting. FG values were compared between the two groups.
RESULTS
Twenty-one patients (42 ears) completed the study. Thirty-one ears (73%) were classified as well-fitting. Although HA gain was adjusted toward the target 1/3 G, measured FG values at 250 and 500 Hz remained lower than the target values. In well-fitting ears, low-frequency FG values were lower than the target 1/3 G, whereas FG at 2000 Hz was close to the target value. In contrast, non-well-fitting ears showed low-frequency FG values closer to the target 1/3 G, whereas FG values at 2000 and 4000 Hz remained below the target values.
CONCLUSIONS
Although HAs adjusted toward a 1/3 G target did not achieve the intended FG values, particularly at low frequencies, relatively favorable fitting outcomes were obtained in approximately three-quarters of the ears. In well-fitting ears, low-frequency FG remained below the target 1/3 G, whereas FG in the mid-frequency range around 2000 Hz was close to the target value. These findings provide a basis for future prospective studies to clarify how these FG characteristics should be applied to optimize HA adjustment.
A USAF cadet and a Lincoln Laboratory researcher found AI chatbots can help nontechnical service members produce viable software applications for their unique problems.