Reprogramming T cell fate through antibody-mediated galectin-1 blockade.

Melanoma suppresses galectin-9-glycan axis in dendritic cells and galectin-9 restoration limits T regulatory cell expansion

An anti-Galectin-3 intrabody improves primary and memory response of antigen-specific CD8+ T cells during viral infection

Genetic ablation approaches are routinely used to establish gene function, but these are not beyond limitations. The intracellularly expressed camelid single-domain antibodies (sdAbs), or nanobodies, can specifically disrupt molecular interactions and, therefore, help ascertain their role in the process of cellular dif...

Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming

Despite the success of immune checkpoint blockade in cancer therapy, overcoming the immunosuppressive tumor microenvironment remains a major barrier to durable responses. Here, we introduce cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4)-targeting chimeras (cTACs), a class of synthetic molecules that harness CTLA-...

Reviving low-affinity glycan-targeting CAR with combinatorial design.

CD19CAR T cells demonstrate remarkable therapeutic efficacy in the treatment of B cell malignancies. A global limitation of conventional CD19CAR therapy is its mono-specificity. Thus, defining complementary targets to CD19 is critical to avoid target-dependent limitations. Alternatives to protein antigens include secon...

Dual roles of DDR1 in stromal remodeling and immune escape: a regulator of the tumor immune microenvironment

The current understanding of DDR1 as a central regulator of the tumor immune microenvironment is synthesized and the translational potential and challenges of DDR1-targeting strategies to enhance cancer immunotherapy are discussed.

Galectin-3 and its inhibitors: Overview and perspectives.

Galectin-3, a β-galactoside-binding lectin, is a driver and regulator of inflammation and fibrosis, and its levels are elevated in some heart and lung diseases. It also serves as a biomarker for the risk and severity of some forms of heart failure and, potentially, for various other pathological conditions. These obser...