The core clinical association between sleep disorders and endometriosis remained positive after adjustment for major demographic and lifestyle covariates and the genetic and molecular findings should be interpreted as hypothesis-generating pending prospective and experimental validation.
These findings implicate key mitochondrial genes, particularly DCXR and ACADVL, in the pathophysiology of specific sleep disorder subtypes, highlighting potential avenues for precision medicine.
Jun-Jun Xu, Zi-Ya Zhang, Liu-Yang Yu et al.· Journal of Molecular Neurosc...· 0 citations
Sleep disorders present major public health issues because of their associations with chronic diseases. Despite extensive research efforts, the underlying biological mechanisms remain inadequately understood. We performed bidirectional two-sample Mendelian randomization (MR) to investigate relationships between sleep d...
Zi-Yu Wang, Miao Zhang, Cong Liu et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
It is suggested that sleep disturbances may represent potential modifiable factors associated with mental health outcomes and highlight the importance of sleep-related interventions in psychiatric disease prevention and management.
Xin Wu, Mei Chang, Bing-Yi Song et al.· Frontiers in Psychiatry· 0 citations
Aim
To investigate the causal relationship between genetically predicted sleep duration and breast tumors using a bidirectional two-sample Mendelian randomization (MR) analysis.
Methods
A bidirectional two-sample MR analysis was performed using genome-wide association study (GWAS) summary statistics. The inverse varia...
Li-Tong Shao, Dan Zhao, Jing Ji et al.· The Annals of Clinical and A...· 0 citations
Cross-sectional analysis of NHANES 2007–2018 cross-sectional data found no overall association between sleep disorders and BC, and Mendelian randomization provided suggestive evidence of a modest association between genetically predicted sleep disorders and ER−, but not ER+, BC.
Si-Yan Chen, Jian-Di Li, Ke-Jun Wu et al.· World Journal of Oncology· 0 citations
The integration analysis showed that genetic variants and DNA methylation at sites annotated to the FADS gene cluster were linked with lipid species that were also associated with lifetime MDD status, while introducing DNA methylation as an additional molecular layer supporting this link.
H. Smith, A. Richmond, M. Adams et al.· medRxiv· 0 citations
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