Age-associated signal is accessible to a pooled cross-species model, but which genes carry it depends on how the model encodes expression; which genes carry it depends on how the model encodes expression.
Aging is a complex process affected by genes and modified by environment. The forefront of aging research has moved from the level of organisms to the level of tissues and single cells, analyzed using bulk tissue and single-cell transcriptomes. Transcriptomics provides high resolution, comprehensive information per sam...
Stewart A. Frankel, B. Rogina· Frontiers in Genetics· 0 citations
This work proposes a 'collective maintenance' model in which motif vocabularies defining cell type families are evolutionarily stable, while recombination of these motifs generates cell type-specific regulatory programmes.
Chew Chai, Jesse Gibson, Peng-Yang Li et al.· Nature Ecology & Evolution· 1 citation
Abstract Enhancer RNAs (eRNAs) contribute to gene expression specificity, yet their expression patterns at single-cell resolution remain poorly understood. Across 184 329 high-quality single cells from 187 full-length single-cell RNA-seq datasets, we identified 85 977 human and 82 727 mouse eRNAs, which were sparsely d...
Hao Rong, He-Ting Liu, Yan-Guo Li et al.· Nucleic Acids Research· 0 citations
The findings show that the pervasive effects of human neuronal aging might be linked to the authors' long lifespan and are therefore not evident in animal models.
Emre Caglayan, Ishaan Lamba, Monica Manam Devi et al.· bioRxiv· 0 citations
