Role of hippocampal dentate granule cells in memory: neuronal birth timing matters.

The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation

The subgranular zone (SGZ) of the hippocampus represents a principal site of adult neurogenesis and exhibits distinct structural and organizational features. Increasing evidence indicates that neural stem cell (NSC) behavior in the SGZ is not solely determined by intrinsic cellular properties, but is critically shaped...

Plasticity degeneracy underlies flexible formation and reconfiguration of spatial representations in hippocampal granule cells

Memory processing in neurodevelopmental disorders: linking behavioral, circuits, and molecular scales

Despite long-standing investigations into the neural and molecular correlates of memory, there persists a lack of comprehensive understanding of the cellular and subcellular processes that go awry in cases of neurodivergent and neuropathological phenotypes. While the mechanisms of memory encoding, consolidation, and re...

Distinct prefrontal-amygdala connectivity drives consolidated fear memories

These insights reveal that the consolidated engram requires the targeted engagement of a post-learning engram circuit, rather than a simple reactivation of neurons engaged during initial learning.

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Exposure to 2 weeks of isolation and social defeat stress failed to alter the numbers of BrdU+, or DCX+ cells in the hippocampus or amygdala when evaluated 2 weeks after psychosocial stress, indicating that the current stress paradigm has no long-term consequences on neurogenesis in this primate.

Circuit-specific reorganization of hippocampal-entorhinal-prefrontal subnetworks supports memory recall across the lifespan

The results refine prevailing systems consolidation theories by showing that memory consolidation is a circuit-specific and temporally ordered process, rather than a passive gradual phenomenon, and position the EC as a central and dynamic component of remote memory retrieval alongside the PFC.