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JARID2 inhibition reprograms human hematopoietic progenitor cells to enhance bone marrow transplantation

Jul 2026 · Blood Advances · Vol 10, pp. 6474 - 6488 · 0 citations · 44 references
Medicine

Abstract

Key Points • The genetic inhibition of JARID2 enhances repopulating activity of human HSPCs in vivo.• JARID2 inhibition reinforces stem cell gene expression programs via STAT1 upregulation.

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