Transcriptomic profiling reveals transcriptomic remodeling linked to inflammatory activation and cell cycle-related gene expression in the early hours of macrophage activation

Open access Aug 2026

Transcriptomic Profiling Reveals NF-κB-Associated Immune Regulatory Signatures Underlying the Regenerative Effects of Hypoxia-Preconditioned Tendon Stem Cell-Derived Extracellular Vesicles.

Remodeling of the immune microenvironment is a critical determinant of tissue regeneration, yet the molecular programs associated with the enhanced therapeutic activity of hypoxia-preconditioned extracellular vesicles remain incompletely defined. In this study, we investigated the regenerative and immunomodulatory effe...

Chenfeng He, Chong-Yan Liu, Hong-Xu Zhang et al. · Biofactors · 0 citations

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Open access Sep 2026

CRISPR-Mediated Epigenetic Reprogramming Attenuates Inflammatory Cell Injury Through Targeted Transcriptional Modulation: An Experimental in Vitro and in Vivo Study

Background Persistent NF-κB-driven inflammatory transcription promotes inflammasome activation, oxidative stress, mitochondrial dysfunction, and regulated cell death. Although CRISPR-based epigenome editing enables locus-specific transcriptional regulation without permanent modification of the underlying DNA sequence,...

Hiroshi Takamura, Yuki Nakamura, Rina Fujimoto et al. · Advanced Journal of Biomedic... · 0 citations

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Open access Sep 2026

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single‐cell and bulk transcriptomic analysis

Atherosclerotic plaque progression is shaped by coordinated inflammatory and remodeling programs involving immune cells and vascular wall cells. Inflammatory macrophage activation and vascular smooth muscle cell (VSMC) phenotypic remodeling are central features of human atherosclerosis, but their transcriptomic relatio...

Xin-Yu Dong, Xue-Song Hu, Qi Liu et al. · Journal of cell communicatio... · 0 citations

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Open access Sep 2026

Integrative single-cell and bulk transcriptomic analysis identify R-loop-associated gene signatures driving immune-inflammatory networks in acute pancreatitis

Background R-loop dysregulation has been implicated in chronic inflammation via DNA damage and cytoplasmic ssDNA release, yet its role in acute pancreatitis (AP) remains to be systematically investigated. This study aimed to identify R-loop-related biomarkers in AP and elucidate their potential roles in immune-inflamma...

Lu-Juan Pan, Wei-Bang Wu, Tian-Ying Zhang et al. · Frontiers in Immunology · 0 citations

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Open access Sep 2026

Integrative transcriptomic analysis links epithelial PCK1 dysregulation to ulcerative colitis and acetyl-l-carnitine-mediated inflammatory modulation.

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory disorder characterized by persistent mucosal injury and disturbed immune-metabolic homeostasis. Increasing evidence indicates that metabolic remodeling of intestinal epithelial cells contributes to UC-associated inflammation; however, the key metabolic regula...

Yong-Zhuo Li, K. Yu, He Duan et al. · International Immunopharmaco... · 0 citations

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Open access Sep 2026

Integrated Transcriptomic and Single-Cell Analyses Identify CCR2-Dependent Monocyte–Smooth Muscle Cell Crosstalk in Aortic Aneurysm

Background/Objectives: Aortic aneurysm (AA) involves inflammatory recruitment and vascular smooth muscle cell (VSMC) remodeling, but the cellular contribution of candidate chemokine receptors remains unclear. We prioritized reproducible AA-associated genes, localized their cellular sources, and tested whether monocyte...

Bin-Bin Zhang, Min-Nan Gao, Lu Zhang et al. · Journal of Cardiovascular De... · 0 citations

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