This review comprehensively summarizes medicinal chemistry advances based on the 7-azaindole scaffold from 2020 to 2026, and critically consolidates SAR trends, pinpoints the most frequently successful substitution vectors, and dissects recent clinical failures.
Pyrazinones remain a comparatively underexplored class of nitrogen heterocycles, despite their recurrence in bioactive natural products and their emergence as a privileged scaffold engaging viral polymerases, kinases, proteases, and G-protein-coupled receptors. Unlike prior reviews, typically confined to a single thera...
N. Agrawal, Priya Kushwah, Shilpi Pathak· Medicinal chemistry· 0 citations
Quinoline derivatives are a class of heterocycles featuring a fused benzene-pyridine scaffold that have attracted notable interest in anticancer drug discovery owing to their favourable physicochemical properties, structural versatility and broad biological activities. Accumulating evidence indicates that quinoline-bas...
Yuwen Zeng, Yue Yan, Shi-Ye Wu et al.· Molecular Medicine Reports· 0 citations
This review comprehensively summarizes recent advancements in the structural optimization of pyrazolone‐based compounds, highlighting how molecular hybridization drives polypharmacology against complex conditions, including neurodegenerative disorders, inflammation, metabolic syndromes, cancer, and infectious diseases.
Ke-Long Tang, Yao Liu, Jingning Luo et al.· ChemMedChem· 0 citations
An overview of the recent primary literature concerning the development of s-triazine-based antitumor agents is provided, focusing on the most potent compounds acting on specific molecular targets and discussing the structure-activity relationships (SARs), when available.
Doralice Giorgini, Jacopo Castagnoli, Lorenzo Filidei et al.· Mini-Reviews in Medical Chem...· 0 citations
The escalating crisis of multi-drug-resistant pathogens necessitates the development of novel therapeutic scaffolds with enhanced membrane permeability and multi-target inhibitory potential. This study describes the design, synthesis, and mechanistic evaluation of five novel azo-sulfonamide hybrids (4a–e) derived from...
Samar H. Ali, M. El-Zahed, Elham Negm et al.· Asia-Pacific Journal of Scie...· 0 citations
The literature surveyed here shows that quinoline derivatives continue to serve as a versatile scaffold for generating new leads, linking established synthetic chemistry with current mechanistic and computational approaches.
A. El-mrabet, A. Haoudi, Amine Ez‐zoubi et al.· Scientia Pharmaceutica· 0 citations
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