It is hypothesized that SCS improves the neuromotor control of arm movement by strengthening both excitatory and inhibitory circuit function, and it is shown in three individuals with post-stroke motor symptoms that SCS enhances postsynaptic Ia reciprocal inhibition.
Abstract
Summary Epidural spinal cord stimulation has been shown to be a promising neurotechnology to improve upper limb function in people affected by stroke. It is well established that spinal cord stimulation (SCS) targeting the dorsal root entry zone increases excitatory drive to α-motoneurons via the monosynaptic reflex pathway. However, the effects of SCS on inhibitory neural pathways remain unexplored. We hypothesized that SCS improves the neuromotor control of arm movement by strengthening both excitatory and inhibitory circuit function. We show in three individuals with post-stroke motor symptoms that SCS enhances postsynaptic Ia reciprocal inhibition. These changes correlate with enhanced muscle coordination and arm kinematics, resulting in smoother and faster trajectories. Our study provides further insights into the neural targets of spinal cord stimulation and the use of this technology to treat post-stroke motor deficits. This study was registered at ClinicalTrials.gov (NCT04512690).
Percutaneous spinal cord epidural stimulation (pSCES) is an effective modality for managing pain. However, the use of pSCES in restoration of motor control after SCI is still under research exploration. Today, the effects of postural changes on pSCES-motor control are still controversial. Two participants with complete...
Sohale Hessavi, W. Schroeder, Ahmad M. Alazzam et al.· Spinal Cord Series and Cases· 0 citations
Shoulder motor impairment after stroke restricts reaching, self-care, balance reactions, and the use of mobility aids. Paired vagus nerve stimulation (pVNS), in which brief cervical vagus nerve stimulation is temporally coupled to task-specific rehabilitation, improves overall upper-extremity impairment and activity in...
Xiang Ji, Wei-Ran Zheng, Wei Ma et al.· Frontiers in Neurology· 0 citations
BACKGROUND
Spinal cord stimulation is emerging as a novel approach to restore movement in patients affected by spinal cord injury. Recent advances have shown restoration of locomotion in patients with complete motor lesions using sophisticated new systems including a brain machine interface. Despite the great potential...
F. Agnesi, D. Emedoli, Luigi Albano et al.· i Medicina· 1 citation
Abstract Well-established evidence supports cross-modal interactions of sensory brain plasticity. Here, we extend cross-modality beyond the boundaries of sensory regions and provide first-time evidence in adult healthy humans that motor plasticity influences homeostatic visual plasticity. To this end, we employed repet...
İzel D. Sarı, Vasileia Papakosta, Xavier Corominas Teruel et al.· Cerebral Cortex· 0 citations
After cervical spinal cord injury (cSCI), upper airway dysfunction is highly prevalent, including a dramatically increased incidence of obstructive sleep apnea and swallowing dysfunction. While these deficits have often been attributed to secondary sources such as damage from complications of injury management or anato...
Alyssa Mickle, Jesús D. Peñaloza-Aponte, Caitlin Brennan et al.· Journal of Neurophysiology· 0 citations
Future progress in SCS will likely depend on artificial intelligence, remote monitoring, biomarker-guided programming, and integration with multidisciplinary chronic pain care.
Nafay Abdul, Milan Patel, Rohit Aiyer et al.· Journal of Clinical Medicine· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
