Exercise Regulates Mitochondrial Quality Control: Maintenance and Remodeling of Skeletal Muscle Homeostasis

The hallmarks of skeletal muscle health

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single‐cell, multi‐omics, and translational studies show that aged muscle is shaped by coordinated changes in myofibers, stem and stromal cells,...

Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10‐day bed rest in older adults

This work aimed to characterise how physical inactivity impacts mitochondrial function, morphology and gene expression in the skeletal muscle of older adults.

Autophagy in sarcopenic obesity: muscle-adipose crosstalk, metabolic regulation, and exercise-based interventions.

Sarcopenic obesity (SO) is a complex age-related phenotype characterized by the concurrent presence of reduced skeletal muscle mass, impaired muscle function, and excessive adiposity, which collectively contribute to metabolic dysfunction, physical decline, and increased mortality. Autophagy maintains cellular homeosta...

Mechanistic interactions of diet, exercise, and pharmacotherapy in skeletal muscle metabolism: evidence and translational perspectives

Skeletal muscle plays a central role in whole-body energy homeostasis, metabolic flexibility, and insulin sensitivity, acting as a key integrator of nutritional, mechanical, and pharmacological signals. Although diet, exercise, and pharmacotherapy are often investigated as separate interventions, they converge on share...

Mitochondrial homeostasis in heart failure with preserved ejection fraction: from metabolic remodeling to multi-organ crosstalk

Heart failure with preserved ejection fraction (HFpEF) represents a predominant heart failure phenotype characterized by intricate pathophysiology and an escalating global prevalence. Beyond classical hemodynamic disturbances, emerging evidence identifies mitochondrial dysfunction as a central mechanism in HFpEF pathog...