2026· Advances in Experimental Medicine and Biology· Vol 1517, pp.
167-176
· 0 citations
Medicine
TL;DR
How histone modifications contribute to transcriptional competence, repression, and lineage priming, how these processes vary across species, and how they together constitute an epigenomic "rebooting" that balances the erasure of parental memory with the preservation of essential regulatory information are discussed.
Current knowledge on the role of m6A RNA methylation in mammalian oocyte developmental competence and early embryogenesis is summarized, highlighting recent experimental evidence and discussing potential implications for fertility and assisted reproductive technologies.
Chiara Cosseddu, S. Succu, F. Mossa et al.· Frontiers in Veterinary Scie...· 0 citations
Advances in single‐cell genomics and embryo modeling are transforming the understanding of human early embryogenesis, revealing molecular and epigenetic features that distinguish human development from that of model organisms.
Atsushi Fukuda· Reproductive Medicine and Bi...· 0 citations
Metazoan genomes typically encode several linker histone variants, often expressed in a tissue- or developmental stage-specific manner. The Drosophila melanogaster genome contains only two linker histone variants: H1 is present in somatic cells, while BigH1 substitutes H1 in the germline and early embryos. In the early...
Ramóna Pék, A. Pettkó-Szandtner, Anikó Szabó et al.· The FEBS Journal· 0 citations
An optimized low-input Cleavage Under Targets and Release Using Nuclease (CUT&RUN) workflow tailored for fluorescence-activated cell sorting (FACS) isolated NCCs from zebrafish embryos is presented and can also offer insights into epigenetic dysregulation associated with disease.
Ayesha Nasreen, Sribas Chowdhury, Vivek T. Natarajan· Methods in Enzymology· 0 citations
Many epigenetic regulators play essential roles in animal development, but precisely how they function across different cell types without clear sequence preferences remains a foundational challenge. Here, we employed single-cell RNA sequencing to survey the mutant phenotypes of 30 essential regulatory pathways across...
Yusuke Kijima, JoAnne Villagrana, Min-Ming Wang et al.· bioRxiv· 0 citations
Findings reframe mitochondria as active participants in early human developmental programming, with implications for lineage specification, epigenetic regulation, and the optimization of in vitro embryo culture conditions.
Andrew J. Piasecki, Melissa Franco, Fausto Capelluto et al.· Reproduction· 0 citations
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