Novel Antioxidant Heptapeptide Derived from Yak Bone Collagen Attenuates UV-Induced Skin Photoaging of Mice by Activating the Keap1/Nrf2 Signaling Pathway and Restructuring Skin Microbiota

Protective Effects of a Mixture of Propolis and Petasites japonicus Against UVB-Induced Photoaging Through Suppression of Oxidative Stress and MAPK/AP-1 Signaling

Ultraviolet B (UVB)-induced photoaging is associated with oxidative stress, inflammation, and extracellular matrix (ECM) degradation. This study investigated the protective effects of a mixture of propolis and Petasites japonicus (PPJM) against UVB-induced photoaging in SKH-1 hairless mice. HPLC analysis identified bak...

Integrated phytochemical and network pharmacology revealing anti-photoaging, anti-inflammatory, and antioxidant activities of Tricholoma matsutake extracts

This study investigates the anti-photoaging effects of ethanol extract of Tricholoma matsutake (S. Ito & S. Imai) (TME). UHPLC-Q-Orbitrap-MS analysis identified 68 components, highlighting L-pyroglutamic acid as a primary bioactive constituent. In a UVB-induced mouse model, the topical application of TME significantly...

Retinol versus epigallocatechin-3-gallate (EGCG): Effects on molecular expression in photoaging

Photoaging is a form of skin aging caused by chronic exposure to ultraviolet radiation. It is characterized by dermal matrix degradation, reduced collagen production, and accelerated collagen breakdown. In this randomized parallel-group clinical trial, 26 women aged 30-50 years with glogau II-III photoaging were random...

Protective effects of Oroxylum indicum seed extract against ultraviolet-induced skin photodamage through inhibition of STING and NF-κB signaling pathways.

Polysaccharides from Sargassum fusiforme attenuate UV-induced skin photoaging via epidermal repair and dermal matrix reconstruction.

Skin photoaging is a multifaceted dermatological disorder induced by extrinsic influences (mainly excessive/prolonged exposure to ultraviolet (UV) radiation and intrinsic factors (e.g. oxidative stress), involving progressive disruption of epidermal homeostasis and dermal extracellular matrix (ECM) integrity. This stud...

A Preliminary Study on the Effect and Mechanism of Antarctic Krill Peptides AKP on Alleviating UV-Induced Skin Photoaging by Regulating Estrogen Signaling Pathway

Chronic ultraviolet (UV) exposure is a primary driver of skin photoaging, yet safe and effective natural interventions remain limited. This study investigated the anti-photoaging potential and mechanism of Antarctic krill peptides (AKP), a low-molecular-weight oligopeptide mixture (Mw ~331 Da, with 82.82% < 500 Da) pre...