Aug 2026· Bioinformation· Vol 22, pp. 5057-5061· 0 citations
TL;DR
Data shows the rise of A. baumannii strains that are co-producing OXA and NDM enzymes is an indication of the transition to pan-drug resistance, and combined molecular surveillance and stewardship measures are in urgent need.
Abstract
The growing rise of the occurrence of Carbapenem-Resistant Acinetobacter baumannii (CRAB) in critical care units is a disaster of the existing antimicrobial protocols, with the main cause of this problem being the dissemination of oxacillinase (OXA) and metallo-beta-lactamase (MBL) genes. In the present study, a cross-sectional molecular analysis of 215 clinical isolates was used to assess the antimicrobial susceptibility and define the genotypic presence of blaOXA-23, blaOXA-51 and blaNDM-1 by using multiplex PCR assays in a tertiary care center. The resistance to meropenem was found to be 92.5% phenotypically and intrinsic blaOXA-51 was identified in 100% of isolates with acquired blaOXA-23 (78.6) and blaNDM-1 (34.4) in 22.3%. Thus, data shows the rise of A. baumannii strains that are co-producing OXA and NDM enzymes is an indication of the transition to pan-drug resistance. Hence, combined molecular surveillance and stewardship measures are in urgent need.
These effusions result in a convergence of Class B metallo-2-lactamases (blaIMP) and Class D oxacillinases (blaOXA) in Klebsiella pneumoniae to produce very difficult to diagnose and treat complex multidrug-resistant phenotypes. Fifteen phenotypic susceptibility testing and multiplex PCR were performed on 185 carbapene...
Carbapenem resistance driven by carbapenemase production in Gram-negative bacteria is a global threat. Carbapenem-resistant Acinetobacter baumannii (CRAb) is a critical priority pathogen listed by the World Health Organization (WHO). While blaOXA-23 and blaOXA-24/40-like are most frequently reported in CRAb, an increas...
Hanife Tutan, Bilge Mazlumoğlu, Leyla Genç et al.· Acta Microbiologica et Immun...· 0 citations
It is indicated that blaOXA-23 is the predominant contributor to carbapenem resistance among A. baumannii isolates in Baghdad, while blaOXA-24 and blaOXA-58 are also increasingly prevalent.
A. A. Abdulhassan, Hiba Hazim Hamid, Sara Mahdi Al-Lami et al.· Cellular Physiology and Bioc...· 0 citations
Background
Carbapenem-resistant Acinetobacter baumannii (CRAB) is a World Health Organization critical-priority pathogen, but the contribution of blaOXA-23 and blaNDM co-carriage to resistance across antimicrobial classes is poorly defined in southern Vietnam.
Objectives
To describe the carbapenemase gene profile and...
S. Nguyen, M. Nguyen, Duy Nhất Lê et al.· Le infezioni in medicina· 0 citations
Carbapenem-Resistant Pseudomonas aeruginosa (CRPA) is becoming a growing problem in tertiary healthcare facilities with the acquisition of metallo-beta-lactamase (MBL) genes, specifically the Verona Integron-encoded Metallo-beta-lactamase (VIM) gene, making standard 37 -lactam-based treatment of this pathogen ineffecti...
INTRODUCTION
Carbapenemase-producing Enterobacterales (CPE) have widely emerged as a global health threat due to the spread of resistance genes such as New Delhi metallo-β-lactamase (blaNDM) and oxacillinase-48-like β-lactamases (blaOXA-48-like). Data on the molecular epidemiology of CPE in northern Morocco remain limi...
M. El-Hassouni, Asmae Hazzaz, Reda A. Souhli et al.· Journal of Infection in Deve...· 0 citations
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