Terno, a cyclin-interacting protein regulating meiotic exit and sperm differentiation in Drosophila.

CYB-4/CDK-1 coordinates timing of meiotic entry, chromosome morphogenesis and oocyte maturation in C. elegans

A CDC20 allelic series reveals stage-specific control of metaphase-to-anaphase transitions during mitosis and meiosis in rice.

Sec61β Deficiency Disrupts Drosophila Oogenesis Through UPR-Mediated Defects in Germ Cell Proliferation and Differentiation

It is found that knockdown of Sec61β in either germ cells or somatic cells of ovaries causes complete female sterility, with a small size of ovaries from larval to adult stages, significant reduction in germ cell numbers beginning in the late third-instar larval stage and a complete absence of germ cells in pupal and a...

A Meiotic B-type Cyclin Selectively Drives Mitotic Progression and Fidelity in Cancer Cells

Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type cyclin previously thought to function exclusively in female meiosis, is expressed in mitotic cells and interacts with both CDK1 and CDK2. We show that cycl...

Meiotic recombination proteins in cancer.

Although mitotic cells normally suppress the expression of proteins involved in meiosis, a series of meiotic recombination proteins are commonly expressed in cancers, outside of their normal context. Here we review mechanistic and genomic evidence linking meiotic recombination proteins to cancer, focussing on HORMAD1,...

A β-importin supports fusome growth and distribution in Drosophila ovarian germ cells.

Germline cysts, or interconnected groups of germ cells, promote the synchronization of gamete development in vertebrates and invertebrates. In the Drosophila ovary, cyst formation is accompanied by growth of the fusome, a unique endoplasmic reticulum-like organelle. Although structural components of the fusome have bee...