Aug 2026· Bioprocess and biosystems engineering (Print)· Vol 49, pp. 2561 - 2582· 0 citations· 117 references
Medicine
TL;DR
The key technical applications of synthetic biology in amino acid manufacturing are systematically expounded, and major bottlenecks—such as host cell adaptive evolution and metabolic flux balance—are discussed in the context of current synthetic biology strategies.
Organic acids are significant bio-based platform chemicals with extensive application potential. The growing demand for biodegradable plastics, which utilize organic acids as their key monomers to mitigate plastic pollution, has been a major driver accelerating the advancement of organic acid biomanufacturing. This rev...
Su-Ying Wu· Theoretical and Natural Scie...· 0 citations
Recent advances in fully autonomous ncAA biosynthesis for GCE technology across microbial, zebrafish, and mammalian systems are summarized and emerging applications of these biosynthetic strategies in biological research and therapeutic development are highlighted.
Dan Wu, Mengxi Zhang, Yu Hu et al.· Angewandte Chemie· 0 citations
Amino acid-derived drug precursors are essential intermediates in pharmaceutical synthesis because they provide structurally diverse and stereochemically defined building blocks for the development of modern therapeutics. Biocatalysis has emerged as a sustainable alternative to conventional chemical synthesis by enabli...
Rajesh Ram, Laxmi Yadav, Mamta Verma· International Journal of Dru...· 0 citations
5-aminolevulinic acid (5-ALA) is a naturally occurring, metabolically active non-proteinogenic amino acid that serves as a key precursor for the biosynthesis of heme, chlorophyll, and vitamin B12. Due to its high biological activity and versatile physiological functions, 5-ALA has been widely applied in agriculture, me...
Yuan-Yuan Sha, Zi-Xin Teng, Mian-Shen Ge et al.· Journal of Agricultural and...· 0 citations
Aminoglycoside antibiotics are important therapeutic agents in the clinical treatment of Gram-negative bacterial infections; however, the spread of antimicrobial resistance, together with dose-limiting ototoxicity and nephrotoxicity side effects, substantially restricts their clinical utility. Recent advances in synthe...
Amino acids are indispensable biological molecules that traditionally have been recognized as the fundamental building blocks of proteins. Contemporary research, however, has established that their biological functions extend considerably beyond protein synthesis. Amino acids participate in energy production, nitrogen...
P. Jain, Rashmi Jindal, Hemlata R. Yadav· Genetics and Molecular Resea...· 0 citations
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