It is found that ZNF768 modulates the cell cycle, at least in part, by controlling expression of the major pro-proliferative transcription factor E2F1 independently of p53 activation.
Zinc finger proteins are a large family of DNA-binding factors that play key roles in diverse cellular processes including gene regulation, RNA metabolism and cell cycle control. The zinc finger protein ZNF512B has recently been implicated in chromatin organization and transcriptional repression through its direct inte...
Lena W. Paasche, Nadine Daus, Johannes J. Groos et al.· bioRxiv· 0 citations
A critical role for Cdk1-PP2A signaling is highlighted in controlling the orderly degradation of APC/C substrates, ensuring precisely timed assembly of the transcriptional infrastructure that coordinates cell cycle commitment and progression.
Sapir Nachum-Raines, Noy Gamliel, Danit Wasserman et al.· Molecular Biology of the Cel...· 0 citations
Findings not only advance understanding of cell proliferation and cycle regulation but also identify PAFAH1B1 as a candidate gene for further investigation in follicular development.
Yingting He, Yinqi Zhou, Rui-Qi Wang et al.· Frontiers in Cell and Develo...· 0 citations
Precise temporal activation of mitotic genes is essential for proper cell-cycle progression, yet the chromatin-based mechanisms coordinating this process remain incompletely understood. The B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and becomes hyperactivated following inhibition of the ATR-...
Franziska Liss, D. Gertzmann, Devi Bala Murugan et al.· Cell Reports· 1 citation
This review summarizes recent advances in how NF2 regulates YAP/TAZ and AMOT functions, focusing on their roles in tumor formation, metastasis, and angiogenesis.
Yu Wang, Fa-Xing Yu· Cold Spring Harbor Perspecti...· 0 citations
This review provides an updated overview of this transcriptional module within the Hippo pathway, discusses how it modulates gene transcription to contribute to development and disease, and proposes outstanding questions that warrant further investigation in future studies.
Xiao-Lei Cao, Mei Tang, Zezhen Lu et al.· Cold Spring Harbor Perspecti...· 0 citations
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