Atypical E2F transcription factors couple Polycomb Repressive Complex 2 to endosperm cell division and differentiation

Polycomb protein ZmEMF1a restricts endosperm proliferation and directs differentiation via stage‐specific H2Aub1 and H3K27me3 landscapes in maize

These findings establish ZmEMF1a as an epigenetic regulator that balances endosperm proliferation, cell fate specification, and nutrient accumulation through stage‐specific histone modifications, thereby offering promising targets for enhancing maize yield and nutritional quality.

Polycomb establishes TAD-scale H3K27me3 mega-domains to safeguard neuronal identity

These findings reveal a previously unrecognized role for PRCs in establishing TAD-scale repressive chromatin domains during neuronal maturation, thereby safeguarding neuronal identity from external stimuli through broad silencing of alternative cell fate programs.

Lineage master regulator and cancer-selective partner transcription factors rewire 3D genome topology for tumor-specific gene control

It is shown that p63 reorganizes 3D chromatin topology in squamous cell carcinoma through cooperation with the tumor-selective partner TF, FOXK1, which defines an epigenetic mechanism by which a lineage master TF and tumor-restricted partner TF reshape 3D chromatin structure to drive oncogenic transcription, with impli...

Dynamic Polycomb-CBC crosstalk orchestrates mRNA production at transcriptionally active loci in plants.

Histone modifications and cotranscriptional processing play fundamental roles in regulating eukaryotic gene transcription. Active histone modifications and efficient cotranscriptional mRNA processing act in concert to promote transcription, whereas repressive histone marks are normally depleted from active genes. Howev...

Zinc-finger proteins C3H14 and C3H15 maintain meiocyte identity in flowering plants.

Epigenetic maintenance of PRC2-repressed chromatin requires RTT109 but not H3K56 acetylation.

In animals, plants, and some fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to establish transcriptionally repressed chromatin. Here, we identify the histone acetyltransferase RTT109 as a key regulator of PRC2-repressed domains in the model fungus Neurospora cras...