A novel topical nitroglycerin-lidocaine combination for procedural pain management and rapid cannulation in neonates: results from a randomized controlled clinical trial
Jul 2026· European Journal of Clinical Pharmacology· Vol 82· 0 citations· 49 references
Medicine
TL;DR
Topical lidocaine/nitroglycerin 2% provided rapid analgesia and reduced repeated venipuncture attempts in neonates, offering a practical strategy for pain management in the neonatal intensive care unit (NICU).
Both anesthetic agents produced comparable physiological responses, self-reported experiences, and behavioral reactions during intra-oral local anesthetic injections in cooperative children aged 7–10 years, and the superiority trial did not reveal a statistically significant difference.
Nagah Abdelrahman, M. Al Halabi, M. Kowash et al.· Frontiers in Dental Medicine· 0 citations
Objective: To compare the effectiveness of the two different preoperative nebulization, “Magnesium Sulphate” and “2% Lidocaine” for minimizing the frequency and intensity of post-procedural throat pain among individuals undergoing scheduled laparoscopic cholecystectomy managed with general anesthesia.Methods: A prospec...
Arqam Shaikh, Nuvair Zia, Ali Akram et al.· ANNALS OF ABBASI SHAHEED HOS...· 0 citations
Aim: Wide-awake local anesthesia with no tourniquet (WALANT) is increasingly used in surgical practice due to its safety profile, reduced resource requirements, and elimination of sedation. Although widely studied in hand surgery, its role in emergency thoracic procedures remains unclear. This study aimed to compare th...
Ayça Çalbay, A. Ulaş, S. Gur et al.· The Atlantic Journal of Medi...· 0 citations
Abstract
Pain management is essential in labor. While regional analgesia is the gold standard, it often requires resources and expertise not widely available in low-resource settings. Intravenous paracetamol and intramuscular tramadol are potential alternatives, but their comparative efficacy and safety remain...
Uzoma Ogbonna-Onwukwe, J. A. Adebayo, A. Nweke et al.· International Journal of Med...· 0 citations
Adding magnesium sulfate to 0.5% ropivacaine with magnesium sulfate did not significantly prolong the duration of postoperative analgesia, however, it was associated with reduced postoperative tramadol requirements and increased early sedation, while maintaining haemodynamic stability.
Priya Chandran, KS Santhi, T. Joseph· Journal of Clinical and Diag...· 0 citations