Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt
Open access

Atypical BlaIR Two-Component System in Pseudomonas aeruginosa Regulates Virulence but not β-Lactam Resistance

Jonathan Ho Wing Yin Venus Lau Mila E. Tkatchouk Michael J. Trimble M. Bains Olga Pacios Santamaria Alexandra Redey C. Chan T. Blimkie Negin Ketabchi Patrick K. Taylor Mahta Amanian William W. L. Hsiao Fiona S. L. Brinkman A. H. Lee
Aug 2026 · bioRxiv · 0 citations · 4 references
Biology

TL;DR

Findings indicated that PvmSR contributed to virulence regulation and may serve as a potential anti-virulence target.

DOI Semantic Scholar
Read PDF

Similar papers

Open access Sep 2026

TypA Interacts with ExsA to Suppress Type III Secretion System in Pseudomonas aeruginosa

This study identified tyrosine phosphoprotein A (TypA) as a repressor that restricts expression of the T3SS in P. aeruginosa and reveals a novel molecular mechanism by which P. aeruginosa regulates T3SS.

Li-Wen Yin, Yi-Ming Li, Xue-Tao Gong et al. · 0 citations
Open access 2026

Relationship between quorum-sensing and virulence genes of Pseudomonas aeruginosa isolated from patients, and their association with antimicrobial resistance

Background: Zoonotic diseases are illnesses that humans can contract from animals and vice versa. Pseudomonas aeruginosa is an opportunistic organism that makes treating infections challenging, particularly in individuals with underlying medical conditions and those with impaired immune systems. The increasing number o...

Abdul-Nafea Hassan, Ibtisam Q. Abdulkareem · 0 citations
Open access Aug 2026

R-pyocin-mediated selection reverses pan-drug resistance in Pseudomonas aeruginosa

It is demonstrated that R-pyocins can be leveraged not merely as conventional biocides, but as precise selective forces to drive an evolutionary “checkmate” strategy, establishing a framework for using R-pyocins to force predictable evolutionary trade-offs, driving the reversion of multidrug resistance to an attenuated...

Isaac Estrada, Davina Campbell, G. Welch et al. · 0 citations
Open access Jun 2025

Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulence

Antibiotic resistance and expression of virulence factors can impact the outcome of infection by Pseudomonas aeruginosa. Pathogenesis is often modelled using the P. aeruginosa PAO1 reference strain but laboratory lineages vary in the sequence and activity of MexT, a global regulator impacting virulence, biofilm formati...

Annapaula Correia, Emma J. Manners, Benjamin A. Evans et al. · 0 citations
Open access Aug 2026

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

It is demonstrated that Spongosorites sp-derived bisindole alkaloid (R)-6’-debromohamacanthin B (RDB) exerts dual bacterium-directed and host-directed activities, simultaneously attenuating virulence and biofilm formation while reinforcing host defense and controlling pathological inflammation.

Dan-Dan Li, Hui-Yan Li, Wen-Bo Niu et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.