A Bayesian Longitudinal Model for Imputing Item-Level Missing Data in Trial-Based Economic Evaluations
TL;DR
A Bayesian longitudinal model for imputing item-level missing data in trial-based economic evaluations that accommodates these complexities within a unified framework is developed and can be extended to settings where data may be missing not at random.
Abstract
Trial-based economic evaluations are widely used to assess the cost-effectiveness of healthcare interventions and inform decision-making. Cost and effectiveness outcomes are typically collected using multi-item questionnaires administered at multiple time points, and are often subject to item-level missingness. In principle, imputation (i.e., replacing missing value with estimated or substituted values) should be performed at the item level to fully exploit available information. However, this is rarely implemented in practice due to several statistical challenges, including the longitudinal data structure, cross-item dependence, heterogeneous missingness patterns, and the mixture of skewed cost and count data. In this paper, we develop a Bayesian longitudinal model for imputing item-level missing data in trial-based economic evaluations that accommodates these complexities within a unified framework. The approach combines a transition-model formulation for longitudinal dependence with flexible distributional assumptions and explicit modelling of cross-item relationships, allowing item-level responses of different types to be coherently modelled over time. Motivated by a real-world trial, we demonstrate the flexibility and practical applicability of the proposed approach. We further discuss how the model can be extended to settings where data may be missing not at random.