RNA‐seq Molecular Risk Classification Refines Prognostic Stratification in Childhood B‐Cell Acute Lymphoblastic Leukemia Treated With the CCCG‐ALL‐2020 Protocol: A Real‐World Cohort Study
It is evaluated whether RNA sequencing molecular risk classification improved outcome prediction under Chinese Children's Cancer Group (CCCG)‐acute lymphoblastic leukemia (ALL)‐2020.
Abstract
Clinical risk group and early minimal residual disease (MRD) guide therapy for childhood B‐cell acute lymphoblastic leukemia (B‐ALL) but may not capture all molecular heterogeneity. We evaluated whether RNA sequencing (RNA‐seq) molecular risk classification improved outcome prediction under Chinese Children's Cancer Group (CCCG)‐acute lymphoblastic leukemia (ALL)‐2020.
Abstract Aim Colorectal cancer outcomes are heterogeneous, so greater prognostic discrimination is needed. In this retrospective real‐world analysis, we assessed the prognostic effect of markers of systemic inflammation in a cohort of patients with RAS/BRAF wild‐type metastatic colorectal cancer (mCRC) who received ant...
Jordan W. Appleyard, Faye Elliott, Nancy Sapanara et al.· Colorectal Disease· 0 citations
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable gen...
G. Moorthy, A. Sereika, K. Kaul et al.· Cancer Medicine· 0 citations
PD‐L1 tumour‐cell (TC) and immune‐cell (IC) expression are scored separately in head and neck squamous cell carcinoma (HNSCC) but are often collapsed into a combined positive score, potentially obscuring distinct patterns. In this retrospective, single‐centre cohort of 61 patients with locally advanced, hypopharynx‐pre...
Ning-Ning Wang, Ze-Hui Yun, Fang-Li Cao· Cancer Medicine· 0 citations
Introduction Acute lymphoblastic leukemia (ALL) is a common pediatric malignancy and shows marked genetic heterogeneity. Transcriptomic profiling may improve molecular diagnosis and risk stratification, particularly in admixed Latin American populations. Methods We characterized the transcriptomic landscape of pediatri...
Edward Perez-Arismendi, Natalia Gómez-Lopera, Juan Camilo Villada et al.· Frontiers in Oncology· 0 citations
PURPOSE
WHO5 (2022) classification of B-lymphoblastic leukemia (B-ALL) incorporates several novel entities requiring high-throughput sequencing for their accurate characterization. The clinical relevance of this classification in the context of contemporary measurable residual disease (MRD)-directed therapy is unclear....
S. Rajpal, G. Chatterjee, P. Bhanshe et al.· JCO Global Oncology· 0 citations
Adjusting the risk stratification based on treatment response significantly improved the overall prognosis of T-LBL, and molecular genetic risk factors might contribute to further risk stratification and provide potential therapeutic targets.
Xia Guo, Chao-Ban Wang, Yue-Jia Tang et al.· World Journal of Pediatrics· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
