Skip to content
Review Open access

Understanding primary care physicians’ perceptions of large language model adoption in clinical practice: A qualitative research protocol leveraging the technology adoption behavior framework

Aug 2026 · PLoS ONE · Vol 21, pp. e0355491 - e0355491 · 0 citations · 46 references
Medicine

TL;DR

This qualitative study aims to employ a descriptive qualitative design to explore how primary care physicians perceive the adoption of LLMs in the context of their clinical practice to support the development of policies, practices, and behaviors that support safe and effective LLM integration into health care.

Abstract

Introduction Large language models’ (LLMs’) rapid evolution and intersection with diverse groups and institutions require up-to-date policies, practices, and behaviors to ensure safe and effective implementation. Because physicians play a central role in care provision and face the dual mandate of embracing innovations and safeguarding patient welfare, understanding physicians’ views on LLMs can elucidate the complex interplay of technical, ethical, and professional considerations influencing LLM adoption. Methods and analysis This qualitative study aims to employ a descriptive qualitative design to explore how primary care physicians perceive the adoption of LLMs in the context of their clinical practice. We plan to use semi-structured interviews with purposively sampled primary care physicians from British Columbia, Canada. The data collection will draw on the technology adoption behavior framework, a novel model that integrates the most advanced theories of technological uptake. We expect to use thematic analysis drawing on deductive and inductive approaches to describe physicians’ perceptions. The multidisciplinary research team will prepare and conduct reflexive memos and discussions to ensure nuanced interpretations. Dissemination We aim to disseminate the findings through peer-reviewed journals, professional organizations, and policymaker briefings to support the development of policies, practices, and behaviors that support safe and effective LLM integration into health care. Strengths and limitations The study may provide timely input into relevant policies, practices, and behaviors for policymakers, health professionals, and patients around the use of large language models in health care services. This study uses the technology adoption behavior framework to guide the design of data collection and analysis. The semi-structured interview may reveal the interviewees’ internal views but limits the variety of insights gleaned.

Read PDF

Similar papers

Open access Aug 2026

Primary care physicians’ perspectives on the adoption of large language models in practice: a qualitative study among American and Dutch physicians

This study explores the perspectives of primary care physicians towards adopting large language model (LLMs) tools in primary care. We conducted 15 semi-structured interviews and analyzed these through thematic analysis. The findings indicate that there are several considerations regarding LLM use that drive and limit...

Ilse Super, Harinder Bawa, Onur Asan · 0 citations
Review Open access Jan 2026

Intention to Use Large Language Models Among Clinical Nurses in China With Prior Familiarity With or Experience Using LLMs: A Qualitative Study

Among clinical nurses with prior familiarity with or experience using LLMs, intention to use these tools was reflected in participants’ accounts of perceived value, usability, organizational conditions, risk appraisal, and professional boundaries.

Xu Li, Xu Hu, Huiting Xu et al. · 0 citations
Open access Aug 2026

"Who Provides Support?": A Qualitative Study of Professionals' Perspectives on Aborted Cancer Surgery Based on the Fundamentals of Care Framework.

Maintaining safe, person-centered care for patients undergoing aborted cancer surgery is hindered by organizational, cultural, and policy-related barriers within the care context, and the contact nurse remains a key facilitator of person-centered care.

Carina Wennerholm, Anna Persdotter, Tina Gustavell et al. · 0 citations
Review Open access Sep 2026

Facilitators and barriers to implementing AI-assisted diagnostic systems in primary healthcare services in low-resource settings: a mixed-methods study protocol

Although AI-assisted diagnostic systems are increasingly deployed in primary care globally, evidence from multiple countries indicates that deployment does not necessarily ensure clinical uptake. Resource-constrained and dispersed regions face implementation challenges, yet the mechanisms remain unclear. This mixed...

Jun-Han Mu, Can Li, Ting-Ting Kang et al. · 0 citations
Open access Feb 2026

Systemic barriers to the quality of online healthcare consultation: A qualitative study of provider-side factors and incentive misalignment

Objective This study examines healthcare professionals’ perspectives to identify the organizational and systemic factors influencing Online Healthcare Consultation (OHC) service quality, clarify key challenges, and establish directions for future research. Methods Between October 2021 and January 2022, a qualitative st...

Wei Zhang, Mengqiao Zhao, Jingjing Liu et al. · 0 citations
Open access Sep 2026

Scaling up Independent Prescribing across the community pharmacy workforce: Insights from an evaluation of new models of pharmacist-led patient care

Background: Primary care in England has long focused on general practice, but with rapidly increasing demand for care that can support people with long-term conditions in the community, and a workforce crisis resulting in patients struggling to access services equitably – innovative models of integrated care are necess...

Ada Akira Moss, I. McDermott, E. Schafheutle et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.