The role of STRA6 induced by ONECUT2 drives malignant progression and radioresistance in rectal cancer through activating the Wnt/β-Catenin signaling pathway
STRA6’s function was clarified and ONECUT2 was identified as its upstream transcription factor regulating the Wnt/β-catenin pathway to facilitate RC progression and radiation resistance and provide novel insights into the prognostic and functional role of STRA6.
CDC20, upregulated transcriptionally by GATA6 and post-transcriptionally by METTL3, drove CRC progression, angiogenesis, and immune evasion and reversed the inhibitory effects of METTL3 knockdown on CRC cell malignancy and immune escape.
Yuyu Wang, Xinfei Wang, Yongsheng Chang et al.· Human Cell· 0 citations
Both in vitro assays and in vivo models confirmed that silencing ZNF695 dramatically suppresses CRC cell proliferation, migration, and invasion, while concurrently impeding tumor progression.
Xiaozhun Tang, H. Ke, Ying Huang· Molecular Carcinogenesis· 0 citations
Background Oral squamous cell carcinoma (OSCC) remains a lethal malignancy with a 5-year survival rate below 50%, necessitating the identification of novel therapeutic targets. While the RNA-binding protein HNRNPA0 is implicated in various cancers, its precise role and mechanism in OSCC pathogenesis are undefined. Meth...
Hong Zang, Wei Wang, Bo-Wen Zhao et al.· International Dental Journal· 0 citations
RASAL2-AS1 exerts a tumor-suppressive effect in cervical cancer by functioning as a competing endogenous RNA (ceRNA) that modulates the miR-590-5p/PDCD5 axis and regulates the Wnt/β-catenin pathway.
Ke Yin, Yi Li, Mengying Tang· Hereditas· 0 citations
The miR-326/ETS1/PI3K/Akt axis may serve as a potential diagnostic biomarker and therapeutic target for gastric cancer and inducing dysregulation of inflammatory cytokines.
It is demonstrated that KLF14 can inhibit ESCC EMT at least partially via downregulating MISP expression to block downstream Wnt/β-catenin signaling and suggest MISP as a potential therapeutic target for related malignancies.
