Bacterial Memory to Genome Surgery: A Narrative Review of the CRISPR Systems, from Repeated Sequences to Prime Editing
CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing---Cas9's programmable double-strand cuts, the Cas12 and Cas13 families' extensions, and prime editin...