Author

A. A. Alameen

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Open access Sep 2026

Impact of Cannabidiol and Its Synthetic Derivative on Fentanyl Consumption and Fentanyl-Induced Neurometabolic Alterations in Mice

Background: Opioid use disorder (OUD) remains a critical global health challenge, with highly potent synthetic opioids like fentanyl contributing to overdose deaths. The available treatments have limitations. The endocannabinoid system has emerged steadily as a therapeutic target for the opioid crisis due to its modula...

Dalal A. Alkhelb, Jomana M. Alahmadi, Maisa S. Alqarni et al. · Molecules · 0 citations

Open access Sep 2026

Genome-guided prebiotic fermentation generates anti-virulence metabolites against Pseudomonas aeruginosa

Genome-informed glycan-utilization predictions identified substrates capable of producing probiotic metabolites that attenuate multiple P. aeruginosa virulence phenotypes, and Arabic gum shows particular promise for microbiome-based control of multidrug-resistant P. aeruginosa.

Rasha Elsayim, Monerah S. M. Alqahtani, Malak AlOsaimi et al. · Frontiers in Microbiology · 0 citations

Jul 2026

Directed Mutagenesis of Catalytic Residues in L-Asparaginase II from Salmonella paratyphi: Structural, Functional and Stability Analysis Using In-Vitro, Docking and Simulation Studies.

Findings demonstrate that rational site-directed mutagenesis can effectively enhance both the catalytic efficiency and thermal stability of recSalA and indicate that the introduced mutations preserve the overall protein architecture.

Ejlal Mohamed Abdullah, Mohd Shahnawaz Khan, F. S. Ataya et al. · Applied Biochemistry and Bio... · 0 citations