Directed Mutagenesis of Catalytic Residues in L-Asparaginase II from Salmonella paratyphi: Structural, Functional and Stability Analysis Using In-Vitro, Docking and Simulation Studies.

Ejlal Mohamed Abdullah Mohd Shahnawaz Khan F. S. Ataya Majed S. Alokail Chandra Sourav P. Ankit A. A. Alameen Jeevan Kandel B. R. Jali

Jul 2026 · Applied Biochemistry and Biotechnology · 0 citations · 14 references

Medicine

TL;DR

Findings demonstrate that rational site-directed mutagenesis can effectively enhance both the catalytic efficiency and thermal stability of recSalA and indicate that the introduced mutations preserve the overall protein architecture.

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