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Author

A. Alrashidi

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Open access Aug 2026

A novel green synchronous spectrofluorimetric platform for ultra-trace simultaneous determination of letrozole and bicalutamide in pharmaceutical, biological, and environmental matrices

A green synchronous spectrofluorimetric method was developed to overcome this limitation by improving spectral resolution through synchronous scanning of the excitation and emission monochromators, and demonstrated satisfactory accuracy, precision, selectivity, and reproducible analytical performance.

A. Alrashidi, Galal Magdy, A. Radwan · 0 citations
Jul 2026

Norcantharidin attenuates amiodarone-induced pulmonary fibrosis via modulating miRNA-30a/GSK-3β/β-catenin and oxidative-inflammatory pathways.

It is demonstrated that NCTD exerts potent antifibrotic, anti-inflammatory, and antioxidant effects in AIPF, likely through modulation of oxidative stress, inflammatory cytokines, microRNA expression, and the GSK-3β/β-catenin signaling pathway, highlighting its potential as a therapeutic agent for drug-induced lung inj...

A. G. Abd Elhameed, Eman H. Yousef, Muhammed M. Salahuddin et al. · 0 citations
Open access Jul 2026

Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway

It is demonstrated that Var attenuates doxorubicin-induced cardiotoxicity, and its cardioprotective effects are associated with restoration of the p-AMPK/SIRT1/Nrf2/PPARγ signaling pathway, together with reductions in oxidative stress, apoptosis, and fibrosis.

Eman H. Yousef, M. A. El-Gammal, Muhammed M. Salahuddin et al. · 0 citations
Aug 2026

Metabolomics-guided network pharmacology and molecular modeling suggest bioactive components of Chiliadenus montanus associated with multi-target anticancer and anti-inflammatory activities

Overall, CME activity is associated with modulation of apoptotic and inflammatory signaling pathways, supported by biochemical, cellular, metabolomic, and computational analyses.

Ghazi A. Bamagous, H. Almasmoum, Mazen M. Ghaith et al. · 0 citations
Open access Aug 2026

Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling

Buspirone pretreatment mitigated CPA-induced renal dysfunction, accompanied by increased miR-205 expression, reduced EGLN2 expression, enhanced Nrf2-associated antioxidant defenses, and attenuation of ER stress, inflammation, and apoptosis, thereby preserving renal function and tissue integrity.

Ahmed M. El-Dessouki, A. Alrashidi, Mohammad I Jumaa et al. · 1 citation

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