Mechanical and antibacterial efficacy of minocycline- and curcumin-loaded PLGA nanoparticles coated on dental implants for the treatment of peri-implantitis
Aug 2026· 3 Biotech· Vol 16· 0 citations· 62 references
Medicine
TL;DR
Findings indicate that PLGA-MIN/CUR coatings represent a promising multifunctional strategy for enhancing implant surface performance and preventing or managing peri-implantitis.
Through the synergistic effects of its components, the GO@Ag/SF coating established a dynamic antibacterial-osteogenic balance, offering a promising strategy for the repair of infectious bone defects.
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The CurcloDent coatings demonstrated effective antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa through surface-mediated antimicrobial action, and therefore may help to increase the lifespan of the implant.
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The multifunctional coating provides sustained antimicrobial activity alongside immunomodulatory and pro-regenerative effects, supporting its potential to treat implant-related infections while enhancing peri-implant soft tissue remodeling.
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