A. Bhaduri

Glioma and ependymoma through the lens of brain development, stem cells, and plasticity.

Temporal mapping of radiation-induced neural injury and mitigation in human cortical organoids

Human cortical organoids recapitulate key features of radiation-induced neural injury, recovery, and therapeutic modulation, providing a robust, scalable, and human-relevant platform for studying CNS radiation biology and preclinical screening of candidate radiation mitigators.

Exosome-Mediated Bidirectional Signaling Regulates Glioma Stem-Cell Homeostasis and Radiation-Induced Plasticity

Exosome-mediated intercellular communication is identified as a potential mechanism regulating GBM cellular homeostasis, treatment resistance, and recurrence and is used to establish a bidirectional feedback circuit between stem-like and differentiated tumor-cell compartments.

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan

A consolidated cellular-resolution transcriptomic atlas of human brain development from the onset of neurogenesis to adulthood is presented, covering ∼2.2 million cells from 156 donors across nine studies, and dynamic gene programs predictive of cell-type maturation are identified.