Navigating off-target effects in CRISPR-based genome editing for safer gene therapies
The molecular basis of off-target cleavage across three nuclease platforms is examined, with emphasis on mechanistic and structural factors that govern mismatch tolerance, and directions for improving standardisation, expanding structural variation surveillance, and extending safety characterisation to the full diversi...
A. Bhardwaj
· Discover Genetics and Evolut... · 0 citations