Author

A. Boettiger

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Open access Sep 2026

Multiscale spatial analysis implicates chromosomal metaloops in gene patterning across the Drosophila brain

Scores of chromosome-scale loops, or metaloops, arise in the Drosophila brain, but their spatial organization and relationship to neural gene expression patterns remain unclear. Here, we used multiplexed Optical Reconstruction of Chromatin Architecture (ORCA) to examine the multiscale spatial organization of metaloops...

Aleena L. Patel, Achuthan Raja Venkatesh, Tohn Borjigin et al. · bioRxiv · 0 citations

Jul 2026

Promoter strength and position govern promoter competition through transcript-dependent insulation

The rules governing promoter competition are uncovered, its impact on tuning gene expression levels and genome evolution is highlighted, and it is suggested that transcriptional units producing transcripts of sufficient level and length can mediate insulation independently of CTCF and cohesin.

Mervenaz Koska, Masahiro Nagano, Tomek Swigut et al. · Nature Genetics · 1 citation