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Author

A. Casiraghi

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Review Open access Aug 2026

Oral absorption of high molecular weight polyethylene glycols: mechanistic, safety and regulatory insights

The gastrointestinal absorption of macromolecules represents a major challenge in both drug development and regulatory evaluation, as the intestinal barrier is highly effective in limiting the systemic uptake of large molecules. Nevertheless, understanding the mechanisms that govern macromolecule permeability is essent...

C. Gennari, Sara Azari, A. Casiraghi et al. · 0 citations
Jul 2026

Real-life application of the Optical Beta-Adrenergic Sweat Test for people with cystic fibrosis.

SDN detected an earlier response to CFTR modulators, yielding lower p-values than the C/M rate ratio, particularly during ETI therapy, which provides a simpler and faster method than C/M ratio for monitoring the effects of CFTR modulators on CFTR function.

K. Kleinfelder, Anca Manuela Hristodor, G. Centin et al. · 0 citations

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