Author

A. Citro

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#gene editing Open access Oct 2026

The capsule was never just a capsule: what islet encapsulation is for, now that immunoisolation is no longer its job

For more than four decades, islet encapsulation has been defined by a single objective: to immunoprotect transplanted cells while preserving glucose sensing and insulin delivery, thereby eliminating systemic immunosuppression. No passive device has yet achieved that objective with reproducible, durable and clinically m...

A. Citro, Lorenzo Piemonti · Frontiers in Bioengineering... · 0 citations

Review Open access Aug 2026

Hypoimmune platforms: from rejection to immune evasion and regulatory implications

This review summarizes current strategies for engineering immune-evasive grafts that simultaneously suppress adaptive and innate immune responses and outlines the safety considerations and remaining limitations in immune evasion that must be addressed to enable clinical implementation.

Francesco Campo, Maria Irene Bellini, Hanne Scholz et al. · Transplant International · 1 citation