Open access
Jul 2026
Coordinated Immune Activation Following KRAS Inhibition in Syngeneic Models Reveals Molecular Pathways that Potentiate and Limit Antitumor Immunity
Using KRAS and MEK inhibition, the authors demonstrate altered neoplastic cell fates and immune functions of cDCs, T cells, and macrophages. Addition of KRAS inhibition to PD-1 blockade enhances T cell– and macrophage-mediated antitumor immunity.
Daniel R Lu, T. Osgood, Shining Ma et al.
· Cancer immunology research · 0 citations