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Coordinated Immune Activation Following KRAS Inhibition in Syngeneic Models Reveals Molecular Pathways that Potentiate and Limit Antitumor Immunity

Daniel R Lu T. Osgood Shining Ma Huajia Zhang Matt Kanke Jessica A. Tan Siddhi N. Paudel Hong Zhou Juan Estrada Tracy Yamawaki K. Tarbell Karen Rex J. DeVoss Scott E Martin Songli Wang Jude Canon J. Lipford A. Coxon Chi-Ming Li
Jul 2026 · Cancer immunology research · Vol 14, pp. 1433 - 1453 · 0 citations · 77 references
Medicine

Abstract

Using KRAS and MEK inhibition, the authors demonstrate altered neoplastic cell fates and immune functions of cDCs, T cells, and macrophages. Addition of KRAS inhibition to PD-1 blockade enhances T cell– and macrophage-mediated antitumor immunity.

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