Open access
Jul 2026
Multiscale alterations and cortex-wide organizational trends in focal cortical dysplasia
E. Sahlas, Judy Chen, Arielle Dascal et al.
· bioRxiv · 0 citations
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A hypometabolic gradient is identified in TLE, which covaries with cytoarchitectonic organization, microstructural changes, and hippocampal-neocortical interactions and provides a biologically grounded framework for precise surgical planning, emphasizing that targeting severe hypometabolism may optimize prognosis.